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Charactering Amyloid-Beta Protein Misfolding from Molecular Dynamics Simulation with Explicit Water

โœ Scribed by Lee, Chewook; Ham, Sihyun


Book ID
122209148
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
47 KB
Volume
98
Category
Article
ISSN
0006-3495

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Characterizing amyloid-beta protein misf
โœ Chewook Lee; Sihyun Ham ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 403 KB

## Abstract Extracellular deposition of amyloidโ€beta (Aฮฒ) protein, a fragment of membrane glycoprotein called ฮฒโ€amyloid precursor transmembrane protein (ฮฒAPP), is the major characteristic for the Alzheimer's disease (AD). However, the structural and mechanistic information of forming Aฮฒ protein agg