Channels, Carriers, and Pumps, Second Edition: An Introduction to Membrane Transport

✍ Scribed by Wilfred D. Stein, Thomas Litman

• Publisher: Academic Press
• Year: 2015
• Tongue: English
• Leaves: 416
• Edition: 2
• Category: Library

✦ Synopsis

An introduction to the principles of membrane transport: How molecules and ions move across the cell membrane by simple diffusion and by making use of specialized membrane components (channels, carriers, and pumps). The text emphasizes the quantitative aspects of such movement and its interpretation in terms of transport kinetics. Molecular studies of channels, carriers, and pumps are described in detail as well as structural principles and the fundamental similarities between the various transporters and their evolutionary interrelationships. The regulation of transporters and their role in health and disease are also considered.

• Provides an introduction to the properties of transport proteins: channels, carriers, and pumps
• Presents up-to-date information on the structure of transport proteins and on their function and regulation
• Includes introductions to transport kinetics and to the cloning of genes that code transport proteins
• Furnishes a link between the experimental basis of the subject and theoretical model building

✦ Table of Contents

Content:
Front-matter, Pages i-iii
Copyright, Page iv
Dedications, Page v
Preface to the First Edition, Pages xi-xii
Preface to the Second Edition, Pages xiii-xiv
List of Symbols, Pages xv-xvi
Chapter 1 - Structural Basis of Movement Across Cell Membranes, Pages 1-36
Chapter 2 - Simple Diffusion of Nonelectrolytes and Ions, Pages 37-80
Chapter 3 - Ion Channels Across Cell Membranes, Pages 81-130
Chapter 4 - Carrier-Mediated Transport: Facilitated Diffusion, Pages 131-178
Chapter 5 - Coupling of Flows of Substrates: Antiporters and Symporters, Pages 179-246
Chapter 6 - Primary Active Transport Systems, Pages 247-328
Chapter 7 - Regulation and Integration of Transport Systems, Pages 329-393
Appendix - Fundamental Constants, Conversion Factors, and Some Useful Approximations, Pages 395-396
Index, Pages 397-406