Channel Sharing in Pancreatic β -Cells Revisited: Enhancement of Emergent Bursting by Noise
✍ Scribed by GERDA DE VRIES; ARTHUR SHERMAN
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 347 KB
- Volume
- 207
- Category
- Article
- ISSN
- 0022-5193
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✦ Synopsis
Secretion of insulin by electrically coupled populations of pancreatic -cells is governed by bursting electrical activity. Isolated -cells, however, exhibit atypical bursting or continuous spike activity. We study bursting as an emergent property of the population, focussing on interactions among the subclass of spiking cells. These are modelled by equipping the fast subsystem with a saddle-node-loop bifurcation, which makes it monostable. Such cells can only spike tonically or remain silent when isolated, but can be induced to burst with weak di!usive coupling. With stronger coupling, the cells revert to tonic spiking. We demonstrate that the addition of noise dramatically increases, via a phenomenon like stochastic resonance, the coupling range over which bursting is seen.