Changing Patterns of the Retinoic Acid System in the Developing Retina
✍ Scribed by Peter McCaffery; Katalin C. Posch; Joseph L. Napoli; Lorraine Gudas; Ursula C. Dräger
- Book ID
- 115597025
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 674 KB
- Volume
- 158
- Category
- Article
- ISSN
- 0012-1606
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## Abstract Visual sensation in vertebrates starts with the isomerization of 11‐__cis__ retinaldehyde into all‐__trans__ retinaldehyde. Aldehyde dehydrogenases, present in the pigment epithelium and some retinal cells, convert all‐__trans__ retinaldehyde into all‐__trans__ retinoic acid (at‐RA). Ev
exogenously applied RA has also been used to assess its effects on an teroposterior axial specification in the primary body axis and the central nervous system. In these systems the effects support the prediction that positional signalling molecules are likely to be utilised repeatedly in different