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Changing pattern of breast cancer. Is it a reflection of changing etiology?

✍ Scribed by G. Marie Swanson


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
167 KB
Volume
74
Category
Article
ISSN
0008-543X

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## Abstract About 25–50% of women with Cowden disease, a syndrome associated with germ‐line mutations of the __PTEN__ gene (at 10q23), develop breast cancer (BC), but __PTEN__ mutations have been found in only 5% of sporadic BCs. However, 29–48% of BCs display loss of heterozygosity in 10q23, and a