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Changes of serum adenosine deaminase activity induced by stress in rats

✍ Scribed by Satoru Miyahara; Teruhisa Komori; Koji Shizuya; Junichi Nomura

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 78 KB
Volume: 13
Category: Article
ISSN: 0885-6222
DOI: 10.1002/(sici)1099-1077(199807)13:5<325::aid-hup3>3.0.co;2-7

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✦ Synopsis

Rats were restrained for 4 h or for 4 h per day on three consecutive days and blood samples were obtained 30 min after their release. The adenosine deaminase (ADA) activity in the serum was measured by a micro-method with quantitation of the ammonia generated by ADA. Repeated restraint stress signi®cantly ( p 5 0 . 05) elevated serum ADA activity, while a single 4 h episode of restraint stress had no aect on this activity. It seems possible that the increase in ADA activity in the former case might have been related to the enhanced dierentiation and maturation of suppressor T cells. To our knowledge, the present results are the ®rst to demonstrate that serum ADA activity can be aected by stress.

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