Changes of peripheral t-cell subsets in asplenic w256 tumor-bearing rats

✍ Scribed by Yigong Ge; Han Gao; Xiantao Kong

• Book ID: 102925790
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 801 KB
• Volume: 42
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930420113

✦ Synopsis

In exploring the mechanism of the effect of splenectomy on tumor growth, splenectomized rats and other control rats were implanted subcutaneously with Walker 256 carcinosarcoma cells (5 X 10') on day 10 after splenic operation; meanwhile, peripheral T-lymphocyte subsets were analysed successively. It was found that splenectomy enhanced the rate of tumor appearance and mean tumor diameter and disturbed the equation of Tlymphocyte subsets in peripheral blood, i.e., a subnormal level of Th/Ts ratio. Interestingly, a significant correlation was noted between decreasing values of Th/Ts ratio and increasing average diameters of implanted tumor in splenectomized rats, but not in sham-splenectomized or nonoperated rats with tumor growth. In spleen cells from tumor-bearing rats, a distinct increase of B-lymphocytes and a decrease of T cells were demonstrated. Data from this investigafion provide striking evidence that a relationship exists between enhancement of tumor growth and disproportion of Tlymphocyte subsets in peripheral blood and offer some reasonable explanation for the causes of the promotive role of tumor growth following splenectomy . ~~~