𝔖 Bobbio Scriptorium
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Changes of molecular properties associated with the development of resistance against methotrexate in human lymphoblastoid cells

✍ Scribed by D. Niethammer; R.C. Jackson


Book ID
113145597
Publisher
Elsevier Science
Year
1975
Weight
891 KB
Volume
11
Category
Article
ISSN
0014-2964

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Resistance to 5-azacytidine, a potent inhibitor of the growth of mouse lymphoid leukemia cells in vivo, was achieved in an inbred strain of A K R mice in the third transplant period. The incorporation of orotic acid into the livers of such resistant mice was more than six times lower than in animals