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Changes in water diffusion due to Wallerian degeneration in peripheral nerve

✍ Scribed by Christian Beaulieu; Mark D. Does; Richard E. Snyder; Peter S. Allen

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
692 KB
Volume
36
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The authors report NMR measurements of the changes in water diffusion brought about by in vivo Wallerian degeneration due to either crush‐ or tie‐injuries in the sciatic nerve of the frog. Using a pulsed‐gradient spin‐echo sequence with a diffusion measurement time of 28 ms, the degree of diffusion coefficient anisotropy {D(longitudinal)/D(transverse)} 4 weeks after injury in both crush‐ and tie‐injured nerves (2.3 Β± 0.4 and 1.7 Β± 0.1, respectively) is significantly less than in normal frog sciatic nerve (3.9 Β± 0.4). The decrease of anisotropy in the degenerated nerves is due to both a decrease in longitudinal diffusion and an increase in transverse diffusion. The changes in diffusion coefficients are compared with the degree of axonal and myelin breakdown observed in light and electron micrographs of the nerves.

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