Changes in vascularity and blood volume as a result of photodynamic therapy can be assessed with power Doppler ultrasonography

✍ Scribed by Stefanie Ohlerth; Dagmar Laluhová; Julia Buchholz; Malgorzata Roos; Heinrich Walt; Barbara Kaser-Hotz

• Book ID: 102466995
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 157 KB
• Volume: 38
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/lsm.20282

✦ Synopsis

Background and Objectives: One principal mechanism of photodynamic therapy (PDT) in tumors is destruction of tumor-associated vasculature. In the present study, the vascular effects of PDT in tumors were investigated with power Doppler ultrasonography. Materials and Methods: Seven cutaneous squamous cell carcinomas in cats were treated. Tumors were examined via power Doppler ultrasonography before, 5 minutes, 1 hour, and 24 hours after PDT. Images were digitized for computer-aided assessment of vascularity and blood volume.

Results: Mean baseline tumor vascularity and blood volume were moderate. During PDT, a significant decrease in vascularity and blood volume was noted. Lowest values were found 24 hours after PDT.