Changes in urinary proximal tubule parameters in neonatal rats exposed to cadmium chloride during pregnancy
✍ Scribed by A. M. Saillenfait; J. P. Payan; M. T. Brondeau; D. Zissu; J. de Ceaurriz
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 430 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0260-437X
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✦ Synopsis
Pregnant Sprague-Dawley rats were injected intraperitoneally with physiological saline solution (vehicle) or cadmium chloride (CdCIz) at 2.0 or 2.5 mg kg-' on days 8, 10, 12 and 14 of gestation. On postnatal day (PND) 3, 12 or 49, the offspring were examined for 8or 24-h urinary excretion of Pz-microglobulin (Pz-m), metallothionein (MT) and urinary activity of three proximal tubular enzymes: gammaglutamyl transferase (GGT), alkaline phosphatase (ALP) and Kacetyl-P-glucosaminidase (NAG).
Treatment with CdCI2 did not affect growth or survival of offspring. Significant decreases in the urinary excretion of GGT, ALP and NAG were observed on PND 3, at both doses. Exposure to 4 X 2.5 mg kg-' resulted in functional deficit of the proximal tubule on PND 3, as evidenced by the significant increase in p2m. Except for a slight but significant increase of Pz-m in 49-day-old males, all the other urinary parameters returned to control values on PND 12. There was no effect on MT.
Results from this study show that prenatal exposure to CdClz can induce significant changes in the kidney biochemistry of rats in the early postnatal period.