Changes in tumor proliferation of rectal cancer induced by preoperative 5-fluorouracil and irradiation
β Scribed by Christopher G. Willett; Michael Hagan; William Daley; Gretchen Warland; Paul C. Shellito; Carolyn C. Compton
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 662 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0012-3706
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Glucosamine (GlcN) modulates fluoropyrimidine metabolism and enhances cytotoxicity of 5fluorouridine (FUrd), but not of 5-fluorouracil (FUra), in human tumor models. To elucidate the underlying metabolic differences between FUra and FUrd, by the use of 19 F and 31 P NMR spectroscopy we studied
We have used in vivo 19F NMR spectroscopy to study the metabolism of 5-fluorouracil (FUra) in tumors with and without pretreatment with methotrexate (MTX). Using the CD8F1 murine mammary tumor as an in vivo model, we observed signals from FUra, alpha-fluoro-beta-alanine (F beta ALA), alpha-fluoro-be