Changes in thyroid hormones following liver intoxication with carbon tetrachloride

✍ Scribed by Marisabel Mourelle; Boanerges Rubalcava

• Book ID: 102290048
• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 291 KB
• Volume: 1
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550010308

✦ Synopsis

The metabolism of thyroid hormones was studied after carbon tetrachloride (CC14) liver damage. Thyroxine (T4) and triiodothyronine (T3) levels fell and reached a nadir in the first 24 hours after CCI4 administration. Thyroxine binding globulins (TBG) and thyroid stimulating hormone (TSH) also decreased, reaching their lower values in the same period. Blood and liver T4 turnover measured in CC14 treated rats were faster than in control animals. Therefore, at least three phenomena appear to be involved after CC14 intoxication in rats: (1) increased utilization and turnover of thyroxine by the regenerating liver; ( 2 ) diminished thyroid hormone secretion by the thyroid gland, and (3) proteins. The results support the concept that the T4 which, in turn, control hepatocellular growth. reduced concentration of serum iodothyronine carrier liver participates in the metabolic regulation of T3 and ~