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Changes in the testes following vasectomy in the rat

✍ Scribed by S.W. McDonald; A. Lockhart; D. Gormal; N.K. Bennett

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
505 KB
Volume
9
Category
Article
ISSN
0897-3806

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✦ Synopsis

Six months and more after unilateral vasectomy in the rat, ipsilateral (same side) and bilateral testicular atrophy are common; this paper investigates their etiology. Ipsilateral atrophy is associated with the presence of a sperm granuloma in the head of the corresponding epididymis and appears to be pressure-mediated. That sperm granulomas at the epididymal head fail to relieve intraluminal pressure in the epididymal duct of the rat was supported by a study of the effects of ligation of that region. No histological evidence was found to indicate that bilateral atrophy was the result of an immune response. A radiological study does not support the idea that compression or displacement of testicular blood vessels by sperm granulomas is responsible for bilateral atrophy.

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