## Abstract Teratocarcinoma cells in culture offer an in vitro system for studying certain aspects of embryonic differentiation. To gain some insight into regulatory systems that might be operative during early development, we have characterized the alterations that occur in the hormonal responsive
Changes in the rate of laminin and entactin synthesis in F9 embryonal carcinoma cells treated with retinoic acid and cyclic AMP
β Scribed by Ashley R. Cooper; Amanda Taylor; Brigid L.M. Hogan
- Book ID
- 118873351
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 973 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0012-1606
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Retinoic acid induces the differentiation of PCC4.aza 1R and Nulli-SCC1 embryonal carcinoma (EC) cells. In response to retinoic acid treatment, the levels of cyclic AMP (CAMP)-dependent protein kinases are enhanced in t h e plasma membrane within 17 hours and in the cytosol fractions of these cells
## Abstract F9 embryonal carcinoma cells differentiate in response to retinoic acid (RA). To investigate the regulation of RA receptors (RARs) expression during this process, cDNA probes specific for the major RAR isoforms were used. In contrast to the level of RARΞ²2 mRNA which was high in cells tr
Several differentiation-specific genes, including those for collagen IV and laminin, are induced by retinoic acid IRA) in mouse F9 teratocarcinoma cells. Dibutyryl CAMP can enhance the effect of RA in these cells, but dibutyryl CAMP alone does not induce these genes. Inhibition of RNA synthesis with