In spite of tlic prominent position occupied by the hypoplip i s in moderii biology and mediciiie, relatively little reliable information is available on tlie correlation of tlie histological structure of this gland with developmental and physiological processes iii children. The difference in the relative number of tlie different types of cells in the anterior lobe in newborn (as reported by Halperii, '38) and in adults (Gasmussen, '29, '33a, '36; and Floderus, '44) suggests that a distinct alteration in the proportions of the chromophills take place at some intervening period. A differential cell count has been doiie on so fern children (Halperii, '38, reports on 16 awl Nellgren, '45, 011 6 -the latter all being less than one pear of age) that no general trend is deductible, particularly from a qnan- titative s tandpoint.
Certain general impressions are given by Cooper ( '25) but they are evidently based on rather ljimited material. From it one gets the impression that the prepuberal Iiypophysis is noticeably different from the postpuberal gland in the relative prominence of the different types of cells in the anterior lobe. Fraser ('21) studied sections of 40 hypoyhyses from