Changes in the nuclear uptake and retention of3H-estrogen in gonadotrophs and lactotrophs as a function of age

✍ Scribed by Nogami, H. ;Yoshimura, F. ;Herbert, D. C. ;Aufdemorte, T. B. ;Gates, G. A. ;Holt, G. R. ;Sheridan, P. J.

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 416 KB
• Volume: 212
• Category: Article
• ISSN: 0003-276X
• DOI: 10.1002/ar.1092120311

✦ Synopsis

A quantitative autoradiographic immunocytochemical study was performed in which the nuclear uptake and retention of 3H-estradiol (3H-E2) by luteinizing hormone (LH) and prolactin (PRL) cells was examined in 19-21-year-old baboons. 3H-E2 concentrating cells were found in all of the three lobes of the pituitary in varying percentages (38.7%, pars distalis; 17.1%, pars intermedia; 6.3%, pars nervosa). Approximately 80% of PRL cells and nearly 100% of LH cells were labeled. A count of the number of silver grains over nuclei revealed a marked variation of the accumulation of 3H-Ez by LH cells and to a lesser extent in PRL cells. These results suggest functional heterogeneity among LH and PRL cells. The present results are discussed in relation to the physiological state of old animals.