Changes in the mitotic cycle induced by α-solanine

✍ Scribed by David Kirk; Ursula Mittwoch

• Book ID: 104700428
• Publisher: Springer
• Year: 1975
• Tongue: English
• Weight: 387 KB
• Volume: 26
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00278436

✦ Synopsis

Low concentrations of alpha-solanine stimulated the growth of cultured human fibroblasts, while higher concentrations (greater 30 mug ml-1) had a markedly inhibitory effect. Autoradiographic studies indicated that the stimulation of cell growth was due to a shortening of the G1 phase. Feulgen microdensitometry of cells treated with high doses of alpha-solanine revealed an abnormal accumulation of cells in G2. The response of cultured human fibroblasts to low doses of alpha-solanine is comparable to that of sex hormones on target tissues. It is concluded that by virtue of either its stimulatory or its inhibitory effect on cell growth, alpha-solanine could act as a human teratogen.