Tumorigenesis is thought to be a multistep process in which genetic alterations accumulate to bring about the neoplastic phenotype. Colorectal tumors appear to arise as a result of the mutational activation of oncogenes coupled with the inactivation of several tumor suppressor genes. We have found f
Changes in the expression of syndecan-1 in the colorectal adenoma–carcinoma sequence
✍ Scribed by R. M. Day; Xingpei Hao; Mohammad Ilyas; Peter Daszak; Ian C. Talbot; Alastair Forbes
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 327 KB
- Volume
- 434
- Category
- Article
- ISSN
- 1432-2307
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## Abstract Epigenetic silencing is a prominent feature of cancer. Here, we investigated the expression of DNA demethylase and three DNA methyltransferases during colorectal tumorigenesis comparing the genes encoding DNA methyltransferases 1 (__DNMT1__), 3A, and 3B (__DNMT3A__ and __DNMT3B__) with