Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progression
✍ Scribed by Junko Yoshida; Akiko Horiuchi; Norihiko Kikuchi; Akiko Hayashi; Ryosuke Osada; Satoshi Ohira; Tanri Shiozawa; Ikuo Konishi
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 733 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0918-4287
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## Abstract ZEB1 and SNAIL repress __CDH1__ and induce epithelial–mesenchymal transition (EMT). However, SNAIL and ZEB1 also activate or regulate other target genes in different ways. For instance, vitamin D receptor (VDR), which activates __CDH1__ expression upon ligand binding, is repressed by SN