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Changes in the antinociceptive effect of mesencephalic stimulation produced by analgesics and tranquilizers

✍ Scribed by A. V. Dmitriev; Yu. D. Ignatov


Publisher
Springer US
Year
1978
Tongue
English
Weight
467 KB
Volume
85
Category
Article
ISSN
0007-4888

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Effect of midbrain raphe lesion on the a
✍ R. Samanin; D. Ghezzi; C. Mauron; L. Valzelli πŸ“‚ Article πŸ“… 1973 πŸ› Springer 🌐 English βš– 267 KB

The antinociceptive action of several analgesics was studied by two methods: the hot-plate and the tail compression tests. Lesions of the midbrain raphe, which produce a marked depletion of serotonin in the forebrain, antagonize the analgesic effect of morphine but not that of methadone, meperidine