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Changes in Stability and Allosteric Properties of Aspartate Transcarbamoylase Resulting from Amino Acid Substitutions in the Zinc-Binding Domain of the Regulatory Chains

✍ Scribed by Edward Eisenstein, David W. Markby and H. K. Schachman


Book ID
123636852
Publisher
National Academy of Sciences
Year
1989
Tongue
English
Weight
948 KB
Volume
86
Category
Article
ISSN
0027-8424

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A 70-amino acid zinc-binding polypeptide
✍ Bin-Bing Zhou; Grover L. Waldrop; Lawrence Lum; H. K. Schachman πŸ“‚ Article πŸ“… 2008 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 873 KB

## Abstract Interaction between a 70‐amino acid and zinc‐binding polypeptide from the regulatory chain and the catalytic (C) trimer of aspartate transcarbamoylase (ATCase) leads to dramatic changes in enzyme activity and affinity for active site ligands. The hypothesis that the complex between a C