๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Changes in skeletal muscle gene transcription induced by chronic stimulation

โœ Scribed by Dr. Carol Brownson; Dr. Harvey Isenberg; Dr. Wendy Brown; Dr. Stanley Salmons; Dr. Yvonne Edwards

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
773 KB
Volume
11
Category
Article
ISSN
0148-639X

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โœฆ Synopsis

The mRNA products of four genes, carbonic anhydrase 111 (CAIII), fast myosin heavy chain (MHCf), actin and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), were assayed by Northern and slot-blot analysis in rabbit tibialis anterior and extensor digitorurn longus muscles that were subjected to electrical stimulation for periods of up to 21 days. Marked changes in mRNA levels were seen for all four genes. The mRNA for CAIII, which is specific for type 1 fibers, rose significantly, whereas the MHCf mRNA fell markedly in the stimulated muscles. Changes in GAPDH mRNA were consistent with a reduced dependence on anaerobic glycolysis as an energy source. Actin mRNA levels were noticeably depressed in the early stages of stimulation. Thus for several classes of muscle protein, the response to chronic low-frequency stimulation appears to involve changes at the level of gene transcription.

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