THE PHARMACOKINETICS OF 1954U89, 1, 3-DI
โ
S. D. STUDENBERG; J. L. WOOLLEY; D. V. DEANGELIS; W. A. WARGIN
๐
Article
๐
1997
๐
John Wiley and Sons
๐
English
โ 122 KB
๐ 1 views
1954U89, 1, 3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3, 2-f )quinazoline, is a potent, lipid-soluble inhibitor of dihydrofolate reductase. The pharmacokinetics and bioavailability of 1954U89 were examined in male beagle dogs and male CD rats. Dogs received single intravenous (2ยด5 mg kg 71 )