✦ LIBER ✦

Changes in seizure activity of the neocortex during the early postnatal development of the rat: an electrophysiological study on slices in Mg2+-free medium

✍ Scribed by I. Világi; I. Tarnawa; I. Banczerowski-Pelyhe

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 459 KB
Volume: 8
Category: Article
ISSN: 0920-1211
DOI: 10.1016/0920-1211(91)90077-s

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✦ Synopsis

NMDA receptor-mediated process of rat neocortex slices prepared from 2-24-day-old rats were studied in Mg(2+)-free solution. The response to NMDA application as well as the susceptibility to epileptiform discharges showed age-dependent changes during the first 4 weeks. Slices from the youngest age group seemed to be the most sensitive to NMDA, whereas epileptic activity developed most readily at around the third week.