Changes in muscle T2 and tissue damage after downhill running in mdx Mice

✍ Scribed by Sunita Mathur; Ravneet S. Vohra; Sean A. Germain; Sean Forbes; Nathan D. Bryant; Krista Vandenborne; Glenn A. Walter

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 321 KB
• Volume: 43
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/mus.21986

✦ Synopsis

Abstract

Introduction:

In this study we compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T~2~) in mdx mice.

Methods:

Mice underwent either downhill (n = 11 mdx, n = 6 controls) or horizontal running (n = 9, mdx only) on a treadmill. MRI was conducted prior to exercise, immediately afterward (∽20 minutes), and then 24 and 48 hours after exercise.

Results:

A higher percentage of pixels with elevated T~2~ in the lower hindlimb muscles was observed in the mdx mice compared with controls both pre‐exercise (P < 0.001) and at each time‐point after downhill running (P < 0.05), but not with horizontal running. The medial compartment muscles appeared to be the most susceptible to increased T~2~.

Conclusions:

Downhill running provides a stimulus for inducing acute changes in muscle T~2~ in mdx mice. MRI is a non‐invasive approach for examining acute muscle damage and recovery in multiple muscle groups simultaneously. Muscle Nerve, 2010.