Changes in morphology of in situ forming PLGA implant prepared by different polymer molecular weight and its effect on release behavior
✍ Scribed by Reyhaneh Astaneh; Mohammad Erfan; Hamidreza Moghimi; Hamid Mobedi
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 797 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
✦ Synopsis
The effects of polymer molecular weight on drug release behavior would be more complicated from in situ forming implants (ISFIs) that change gradually from liquid to semi-solid or solid after injection. To investigate this phenomenon, three commercially available D,L-lactic acid-co-glycolic acid (PLGA) polymers with molecular weights of 12, 34, and 48 kDa were used to prepare ISFIs containing leuprolide acetate (LA) as a model peptide. The influence of polymer molecular weight on the membrane formation, morphology, and also on their in vitro drug release behavior over a period of 28 days was investigated. Results showed that the amount of drug released over the first 24 h (36% AE 0.34%) (burst release), for formulation prepared with polymer RG 503H (medium molecular weight, M w 34 kDa), was significantly higher than others ( p < 0.05). Surface and cross-section morphology of ISFI prepared with medium molecular weight polymer to cellular and spongy-like structure which was in good agreement with the release behavior of LA from it.