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Changes in Mitochondrial Rhodamine-123-Fluorescence Populations of Rat Hepatocytes in Primary Culture

โœ Scribed by R. Hernandez-Berciano; M.V. Garcia; C. Lopez-Mediavilla; A. Orfao; J.M. Medina

Book ID
115601586
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
408 KB
Volume
209
Category
Article
ISSN
0014-4827

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The effect of interferon (IFN)-beta and IFN-gamma on P-glycoprotein (P-gp)-mediated efflux of rhodamin-123(Rho-123), a typical substrate of P-gp, was studied in rat hepatocytes in primary culture. After treatment with IFN-beta, IFN-gamma, or both for 3 days, steady-state levels of Rho-123, incorpora