✦ LIBER ✦

Changes in mitochondrial calcium metabolism after treating mastocytoma cells with N6,O2′-dibutyryladenosine 3′,5′ cyclic monophosphate

✍ Scribed by J. E. McHardy; R. K. Ralph

Book ID: 104668150
Publisher: Springer
Year: 1980
Tongue: English
Weight: 539 KB
Volume: 30
Category: Article
ISSN: 0300-8177
DOI: 10.1007/bf00215305

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✦ Synopsis

Comparison of Ca2+ uptake by isolated mouse liver mitochondria, and mitochondria prepared from mastocytoma cells grown with and without N6,O2'-dibutyryladenosine 3',5' cyclic monophosphate (DB cyclic AMP) and theophylline showed several differences in their capacity to take up and retain calcium. In particular mitochondria from DB cyclic AMP-treated mastocytoma cells took up more Ca2+ than mitochondria from untreated mastocytoma cells. Ca2+ uptake by mitochondria from DB cyclic AMP-treated cells was also increased in the presence of oxalate whereas oxalate did not affect Ca2+ uptake by mitochondria from untreated mastocytoma cells and it reduced Ca2+ uptake by mouse liver mitochrondria. The results suggest that inhibiting the growth of mastocytoma cells with DB cyclic AMP alters their mitochondrial Ca2+ metabolism.

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