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Changes in lifestyle and total homocysteine in relation to MTHFR(C677T) genotype: the Inter99 study

✍ Scribed by Husemoen, L L N; Thomsen, T F; Fenger, M; Jørgensen, T

Book ID
110024056
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
118 KB
Volume
60
Category
Article
ISSN
0954-3007

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Linkage disequilibrium of MTHFR genotype
Linkage disequilibrium of MTHFR genotypes 677C/T-1298A/C in the German population and association studies in probands with neural tube defects(NTD)
✍ Stegmann, Karolin; Ziegler, Andreas; Ngo, Ernestine T. K. M.; Kohlschmidt, Nicol 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 32 KB 👁 1 views

A number of studies have demonstrated that the common polymorphism 677C→T in the gene encoding 5, 10-methylenetetrahydrofolate reductase (MTHFR) leads to a thermolabile variant with decreased enzyme activity and to mildly elevated plasma homocysteine. 677TT homozygosity was shown to be more frequent