✦ LIBER ✦

Changes in hepatitis B virus DNA-polymerase activity in patients with chronic infection

✍ Scribed by Dr. A. Alberti; P. Pontisso; G. Realdi

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 427 KB
Volume: 8
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890080402

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Levels of serum hepatitis B virus DNA‐polymerase (HBV‐DNAP) were studied longitudinally over variable periods of time in 16 HBV chronic carriers using a modified assay procedure developed to increase reproducibility. Ten patients were tested on a short‐term basis at 3‐ to 6‐hr intervals for 48 hr or at 24‐ to 48‐hr intervals for 15 consecutive days, and all showed marked vacillations in enzyme levels although hospitalized and untreated. Patients with chronic active hepatitis on liver biopsy had larger fluctuations compared to cases of chronic persistent hepatitis. Six patients were longitudinally tested over a period of 12–32 months and those three receiving immunosuppressive drugs showed a progressive increase in DNAP levels during therapy, but two returned to pretreatment levels after therapy was withdrawn and one even cleared permanently the complete virus with seroconversion to anti‐HBe. Such outcome was also observed in one patient with chronic active hepatitis who remained untreated.

📜 SIMILAR VOLUMES

Leucocyte hepatitis B virus DNA in acute

Leucocyte hepatitis B virus DNA in acute and chronic hepatitis B virus infection

✍ F. Davison; G. J. M. Alexander; Ch. Anastassakos; E. A. Fagan; Roger Williams 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 444 KB 👁 1 views

In the present study we have investigated 53 patients with a spectrum of acute and chronic hepatitis B virus (HBV) infection for the presence of leucocyte HBV-DNA with the aid of molecular techniques. HBV-DNA was detected in peripheral blood mononuclear cells of 31 of 45 (69%) of chronic HBsAg carri

Quantification of intrahepatic hepatitis

Quantification of intrahepatic hepatitis B virus (HBV) DNA in patients with chronic HBV infection

✍ Irene Cacciola; Teresa Pollicino; Giovanni Squadrito; Giovanni Cerenzia; Daniela 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 98 KB 👁 1 views

No data are available about the amount of hepatitis B virus (HBV) genomes in liver of patients with chronic HBV infection. The aim of this study was to quantify the intrahepatic HBV DNA in hepatitis B surface antigen (HBsAg)-positive patients with either active or suppressed viral replication and in

Concurrent hepatitis C virus and hepatit

Concurrent hepatitis C virus and hepatitis delta virus superinfection in patients with chronic hepatitis B virus infection

✍ Yun-Fan Liaw; Rong-Nan Chien; Tong-Jong Chen; I-Shyan Sheen; Chia-Ming Chu 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 476 KB 👁 1 views

## Abstract Since hepatitis C virus (HCV) and hepatitis delta virus (HDV) are transmitted by the same routes as hepatitis B virus (HBV), simultaneous or concurrent HCV and HDV infection in patients with chronic HBV infection may occur. To test this hypothesis and to examine the clinicohistological

Acyclovir in chronic hepatitis B virus i

Acyclovir in chronic hepatitis B virus infection

✍ Geoffrey M. Dusheiko 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 273 KB 👁 1 views

In a previous study a partial inhibition of viral replication was observed in HBeAg-positive patients after acyclovir (ACV) treatment. To assess those results and to evaluate different treatment regimens, a randomized controlled trial with ACV given at 45 mg/kg/day by continuous infusion (in 5 pati

AFP in chronic hepatitis B virus infecti

AFP in chronic hepatitis B virus infection

✍ Yun-Fan Liaw; Anna Lok 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 151 KB 👁 1 views

to be controlled for in comparing immunoprophylactic approaches. At present, DNA polymerase activity or HBV DNA is useful for estimating the level of exposure. In an editorial in this issue, Dr. Dienstag pointed out difficulties in comparing the results of two immunoprophylactic regimens conducted a

Serum hepatitis B virus-DNA cutoff level

Serum hepatitis B virus-DNA cutoff levels in hepatitis B e antigen–negative chronic hepatitis B virus infection

✍ George V. Papatheodoridis; Emanuel K. Manesis; Spilios Manolakopoulos; Athanasio 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 52 KB 👁 1 views

Commitment of bone marrow cells to hepatic stellate cells in mouse. J Hepatol 2004;40:255-260. 6. Kisseleva T, Uchinami H, Feirt N, Quintana-Bustamante O, Segovia JC, Schwabe RF, et al. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J Hepatol 2006;45:429-438. 7. Magnes