Changes in hepatic drug metabolism in alloxan-diabetic male rabbits
β Scribed by Penelope A. Longhurst; Lynn B. Lacagnin; Dee A. Staats; Howard D. Colby
- Book ID
- 115778978
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 492 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0006-2952
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Alloxan diabetes induced in white rats by intraperitoneal injection of alloxan-monohydrate (15 mg/100 g body weight) was used to study changes in the glycogen phosphorylase a and b, phosphoprotein phosphatases and hexokinase activities under insulin deficiency conditions. Among the enzymes studied,
In Dutch-belted rabbits, pregnancy caused several-fold decrease of in vitro hepatic microsomal aminopyrine, benzphetamine, and hexobarbital biotransformations. In pregnant Sprague-Dawley rats, various kinds of expressing the in vitro rates of hexobarbital biotransformation (per mg of microsomal prot