Changes in dendritic spine morphology in response to increased availability of monoamines in rat medial prefrontal cortex
✍ Scribed by Francine M. Benes; Stephen L. Vincent
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 736 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0887-4476
No coin nor oath required. For personal study only.
✦ Synopsis
Theories concerning the etiology of affective disorders and the mechanism of action of antidepressants are centered around monoaminergic transmitters in the brain (Gottfries, 1980;Maas, 1975;Schildkraut and Ketty, 1967). To explore the hypothesis that pharmacological manipulation of cortical monoamines by antidepressant medication may induce structural alteration in synapses in layer VI of medial prefrontal cortex (MPF-VI), the present study has examined the acute effects of the monoamine oxidase inhibitor (MAOI) iproniazid (Kim and D'lorio, 1968;Malenka et al., 1989) on the morphology of pre-and/or post-terminal synaptic elements. This report provides evidence suggesting that acute administration of iproniazid results in alterations of dendritic spines.