Changes in cyclic GMP levels during forelimb regeneration in adult notophthalmus viridescens

✍ Scribed by Liversage, Richard A. ;Rathbone, Michel P. ;McLaughlin, Hooley M. G.

• Publisher: John Wiley and Sons
• Year: 1977
• Tongue: English
• Weight: 380 KB
• Volume: 200
• Category: Article
• ISSN: 0022-104X
• DOI: 10.1002/jez.1402000121

✦ Synopsis

Abstract

Cyclic 3′,5′‐guanosine monophosphate (cGMP) was measured at eight stages of forelimb regeneration in adult newts and compared with the cGMP levels of non‐regenerating control limbs. There was a significant increase in cGMP content during dedifferentiation followed by a sharp decrease to minimal levels at the cone stage. A second smaller increase in cGMP occurred between the cone stage and mid‐differentiation, followed by a decrease to relatively constant levels approaching control values as differentiation progressed. The changes in cGMP during dedifferentiation and during the period of highest cell proliferation indicate that cGMP may play a role in these processes. The smaller increases in cGMP levels during differentiation may reflect a reduced rate of cell division in the differentiating tissues.