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Changes in chromosomal DNA replication patterns in developing frog embryos

โœ Scribed by Stambrook, P. J. ;Flickinger, R. A.

Book ID
102892208
Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
1011 KB
Volume
174
Category
Article
ISSN
0022-104X

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โœฆ Synopsis

Abstract

Continuous exposure of embryonic explants to thymidineโ€H^3^ was used to determine patterns of lateโ€replicating DNA synthesis, i.e. DNA synthesized during the last quarter of the S period, in chromosomes from different germ layers of developing frog embryos (Rana pipiens). Autoradiographic localization of silver grains over chromosomes 1, 7 and 8, as well as unkaryotyped chromosomes, revealed that patterns of lateโ€replicating DNA are similar in determined cells that will undergo different pathways of differentiation. In undetermined early gastrula cells and in differentiated tailbud dorsal axial cells (nerve tube, somites and notochord) more sites of DNA synthesis were lateโ€replicating in chromosomes 1, 7 and 8 and in unkaryotyped chromosomes than in cells of the neural plateโ€dorsal mesoderm of neurulae where differentiation is occurring and in neurula endoderm where determination is taking place.

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