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Changes in cholesterol metabolism in cultured fibroblasts from patients with Niemann-Pick disease

✍ Scribed by J.C. Mazière; C. Mazière; J. Gardette; L. Mora; J. Polonovski


Book ID
118315678
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
297 KB
Volume
102
Category
Article
ISSN
0006-291X

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Sphingomyelinase activity in cultured skin fibroblasts from a fetus affected with infantile-type Niemann-Pick disease was 0.5% of control activity; the activities in cells from two patients with adult-type disease (Cases 2 and 3) were 5.0% and 59.0%. Sphingomyelinase activiy was separated into three