## Abstract The tumor‐suppressor p53 is a multifunctional protein mainly responsible for maintaining genomic integrity. p53 induces its tumor‐suppressor activity by either causing cell‐cycle arrest (G~1~/S or G~2~/M) or inducing cells to undergo apoptosis. This function of wild‐type p53 as “guardia
✦ LIBER ✦
Changes in cellular polyamine contents and activities of their biosynthetic enzymes at each phase of the cell cycle in by-2 cells
✍ Scribed by Su Jin Jang; Hyun Wook Cho; Ky Young Park; Yong-Bum Kim
- Book ID
- 105698466
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 791 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1226-9239
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Regulation of cell cycle progression involves redox (oxidation-reduction)-dependent modification of proteins including the mitosis-inducing phosphatase Cdc25C. The role of vitamin C (ascorbic acid, ASC), a known modulator of the cellular redox status, in regulating mitotic entry was investigated in