Changes in brain catecholamine levels following olfactory bulbectomy and the effect of acute and chronic administration of desipramine in rats
โ Scribed by Katsunori Iwasaki; Michihiro Fujiwara; Shigenobu Shibata; Showa Ueki
- Book ID
- 113220921
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 459 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0091-3057
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๐ SIMILAR VOLUMES
The olfactory bulbectomized (OB) rat has been developed as an animal model of depression. In the novel `open ยฎeld' environment, OB rats showed a hyperactivity which was attenuated by chronic treatment with desipramine (7 . 5 mg/ kg) for 20 days. Neutrophil phagocytosis was suppressed by the lesion,
## Abstract Changes in the dopamine, noradrenaline and dihydroxyphenylacetic acid (DOPAC) concentrations were determined in 6 regions of the rat brain following chronic amphetamine administration for 2 weeks and at intervals of up to 7 days after drug withdrawal. Chronic amphetamine administration