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Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy

✍ Scribed by Stephanie Ann Moran; Nicole Patten; Janice Ryan Young; Elaine Cochran; Nancy Sebring; James Reynolds; Ahalya Premkumar; Alex M Depaoli; Monica C Skarulis; Elif Arioglu Oral; Phillip Gorden

Book ID
116746715
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
80 KB
Volume
53
Category
Article
ISSN
1532-8600

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Severe lipodystrophy is characterized by diminished adipose tissue and hypoleptinemia, leading to ectopic triglyceride accumulation. In the liver, this is associated with steatosis, potentially leading to nonalcoholic steatohepatitis (NASH). We investigated the prevalence of NASH and the effect of l