Changes in blood platelets exposed to UV-B radiation

✍ Scribed by K. Bednarska; B. Wachowicz

• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 392 KB
• Volume: 49
• Category: Article
• ISSN: 1011-1344
• DOI: 10.1016/s1011-1344(99)00057-3

✦ Synopsis

The effects of UV-B radiation (312 nm) on the pig-blood platelet secretory process (platelet activation) and platelet lipid peroxidation have been studied. The responses of platelets to UV-B radiation are compared with the response of these cells to thrombin, which is a strong platelet agonist. The obtained results show that exposure of blood platelets to UV-B radiation (1.2 mW/cm2, 0.072-8.64 J/cm2) causes dose-dependent platelet lipid peroxidation (measured as thiobarbituric acid reactive substances, TBARS) and release of adenine nucleotides and proteins from irradiated platelets. The dose-dependent release of platelet compounds from irradiated platelet does not correlate with the activity of platelet lactic dehydrogenase (marker of cell lysis) in the extracellular medium. It seems that UV-B radiation can partly activate platelets by stimulating the platelet secretory process and metabolism of arachidonate.