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Changes in anti–U1 RNA antibody levels correlate with disease activity in patients with systemic lupus erythematosus overlap syndrome

✍ Scribed by R. M. Hoet; I. Koornneef; W. J. van Venrooij; D. J. de Rooij; L. B. van de Putte

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
717 KB
Volume
35
Category
Article
ISSN
0004-3591

No coin nor oath required. For personal study only.

✦ Synopsis

Objective. To evaluate correlations between changes in a n t i 4 1 RNA antibody levels and disease activity in 9 patients with systemic lupus erythematosus (SLE) overlap syndrome who were prospectively followed up for at least 3 years.

Methods. Anti-U1 RNA antibody levels were measured quantitatively, using a nitrocellulose filter binding assay. Disease activity was measured with a validated SLE activity index.

Results. All 9 major disease exacerbations were associated with peaks in a n t i 4 1 RNA antibody level.

Conclusion. These results seem to indicate that measuring a n t i 4 1 RNA antibody levels can be useful for monitoring disease activity.

Sera from patients with connective tissue diseases often contain antibodies against proteins present in small nuclear ribonucleoprotein (snRNP) particles (1). These snRNPs contain a uridine-rich RNA and

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