Changes in a photoreceptor polypeptide correlating with an early-onset retinal dystrophy in the cat

✍ Scribed by Nigel G. Holmes; Roger Curtis

• Book ID: 104671720
• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 467 KB
• Volume: 107
• Category: Article
• ISSN: 0300-8177
• DOI: 10.1007/bf00225514

✦ Synopsis

A preparation of rod outer segments has been used to study the polypeptides characteristic of an early-onset retinal dystrophy in cats (Rdy) by two-dimensional gel electrophoresis. Comparison of 2-D gels of rod outer segment preparations from retinas of normal and Rdy animals shows several differences. In particular, a polypeptide of Mr 51 kDa and pI 7.5 is present at increased levels in preparations from Rdy cats at 6 weeks, 9 weeks and 12.5 weeks of age but not at 3.5 weeks.