Change of Hepatitis B Virus DNA and Covalently Closed Circular DNA Status in Liver Graft After Liver Transplantation
โ Scribed by Kwon, C.H.D.; Suh, K.-S.; Shin, J.-O.; Kim, S.-J.; Joh, J.-W.
- Book ID
- 122297928
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- English
- Weight
- 195 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0041-1345
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This study examined a signal amplification assay, the Invader assay, for the quantitation of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) in liver biopsies and sera. DNA was extracted from liver biopsy and serum samples were collected from 16 hepatitis B e antigen (HBeAg)-positive
## Abstract Epigenetic factors may modulate chronic Hepatitis B viral infection by affecting virion gene transcription. The aim of this study was to compare the methylation status of the intrahepatic covalently closed circular DNA (cccDNA) CpG island 2 and HBV replication capability. HBV cccDNA was