Change in a complex translocation involving band 7q34 and 9p- in a case of t-cell lymphoblastic lymphoma

✍ Scribed by Kazuma Ohyashiki; A. Iwabuchi; H. Fujieda; A. Suzuki; M. Nakano; J. H. Ohyashiki; K. Toyama; H. Serizawa; R. Amemiya; Y. Hayata

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 472 KB
• Volume: 65
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19900401)65:7<1533::aid-cncr2820650714>3.0.co;2-l

✦ Synopsis

The authors report a case of T-cell type non-Hodgkin's lymphoma (NHL) in which neoplastic cells possessed a three-way translocation involving chromosomal bands 3q21,7q34, and 22q11, as well as partial monosomy of the short arm of chromosome 9. In the literature, most reported cases of 7q32-q36 abnormalities had T-cell type leukemia/lymphoma and were younger than 20 years. Two NHL cases, including the current case, were diagnosed as having lymphoblastic lymphoma with a leukemic transformation. The neoplastic cells of the reported cases commonly showed CD2 (E-rosette receptors) and CD38. All 17 patients but three manifested a mediastinal mass at diagnosis and seven had central nervous system lesions or pleural infiltration. Furthermore, five of the 19 reported cases also showed 9p-change. Cancer 65x1533-1537,1990.

YTOGENETIC INVESTIGATIONS have made it possible

C to identify specific chromosome rearrangements in human leukemia and lymphoma. ' Furthermore, certain genes are mapped at the chromosomal bands which are involved in specific cytogenetic changes, for example, some B-cell type neoplasias have chromosome abnormalities at band 14q32 where the immunoglobulin heavy chain gene (IgH gene) is located. Molecular approaches have proven the biological implications of such chromosomal rearrangements.2 In T-cell type leukemia or lymphoma, specific chromosome change at band 7q32-q36 has recently been reported3-'* and the T-cell receptor (TcR) beta-chain gene has been mapped at band 7q32-+q36.'3.14 Some T-cell neoplastic cells with 7q32-q36 abnormalities have also been shown to involve From the