𝔖 Bobbio Scriptorium
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“Change can happen” by PKA: Proteasomes in in vivo hearts

✍ Scribed by Hiroshi Akazawa; Issei Komuro

Book ID
116985907
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
202 KB
Volume
46
Category
Article
ISSN
0022-2828

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In contrast to the impact of plasma protein binding on pharmacokinetics, no quantitative in vivo information is available on its impact on pharmacodynamics. The pharmacokinetic-pharmacodynamic relationship of the model drug S(À)-propranolol was evaluated using mechanism-based estimations of in vivo