C–halogen…π interactions in proteins: a database study

✍ Scribed by Ishu Saraogi; V.G. Vijay; Soma Das; K. Sekar; T.N. Guru Row

• Book ID: 104432231
• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 503 KB
• Volume: 6
• Category: Article
• ISSN: 1463-0184
• DOI: 10.1016/s1463-0184(03)00068-6

✦ Synopsis

A Protein Data Bank (PDB) study was undertaken to investigate the role of C-X…π interactions (X = F, Cl, Br, I) in protein structures. From this analysis, it is evident that the propensity for the formation of C-X…π interactions is higher in case of fluorine than in other halogens. These results compare well with the recently reported C-X…π interactions in small molecules and depict the orientational dependence of these interactions.