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Challenges in implementing clinical liquid chromatography-tandem mass spectrometry methods - seeing the light at the end of the tunnel

✍ Scribed by Clarke, William; Rhea, Jeanne M.; Molinaro, Ross

Book ID
120936362
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
552 KB
Volume
48
Category
Article
ISSN
1076-5174

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## Abstract A sensitive high‐performance liquid chromatography–tandem mass spectrometry method was developed and validated for the quantification of quetiapine in rat plasma. Following liquid–liquid extraction, the analyte was separated using a gradient mobile phase on a reverse‐phase column and an