Chalcones as novel influenza A (H1N1) neuraminidase inhibitors from Glycyrrhiza inflata

✍ Scribed by Trong Tuan Dao; Phi Hung Nguyen; Hong Sik Lee; Eunhee Kim; Junsoo Park; Seong Il Lim; Won Keun Oh

• Publisher: Elsevier Science
• Year: 2011
• Tongue: English
• Weight: 416 KB
• Volume: 21
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/j.bmcl.2010.11.016

✦ Synopsis

The emergence of highly pathogenic influenza A virus strains, such as the new H1N1 swine influenza (novel influenza), represents a serious threat to global human health. During our course of an anti-influenza screening program on natural products, one new licochalcone G (1) and seven known (2-8) chalcones were isolated as active principles from the acetone extract of Glycyrrhiza inflata. Compounds 3 and 6 without prenyl group showed strong inhibitory effects on various neuraminidases from influenza viral strains, H1N1, H9N2, novel H1N1 (WT), and oseltamivir-resistant novel H1N1 (H274Y) expressed in 293T cells. In addition, the efficacy of oseltamivir with the presence of compound 3 (5 lM) was increased against H274Y neuraminidase. This evidence of synergistic effect makes this inhibitor to have a potential possibility for control of pandemic infection by oseltamivir-resistant influenza virus.