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cGMP reduces the sarcoplasmic reticulum Ca2+loading in airway smooth muscle cells: a putative mechanism in the regulation of Ca2+by cGMP

✍ Scribed by Blanca Bazán-Perkins


Publisher
Springer Netherlands
Year
2011
Tongue
English
Weight
368 KB
Volume
32
Category
Article
ISSN
0142-4319

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The mechanism of down-regulation of L-type Ca(2+) channel (L-VOC) was investigated in rat aortic smooth muscle cells in primary culture. On culture days 3-5, the cells actively incorporated the 5-bromo-2'-deoxy-uridine (BrdU), and did not respond to K(+) depolarization nor express alpha(1C) subunit