Endogenous inhibitory mediators such as prostacyclin and nitric oxide keep platelet activation under tight control through the corresponding cGMP and cAMP signaling pathways. Intracellular levels of cAMP and cGMP are regulated by cyclic-nucleotide phosphodiesterases (PDEs). PDE3A (also known as cGMP
cGMP-dependent protein kinase regulates Rap1 signaling in platelets
✍ Scribed by Albert Smolenski; Meike Hoffmeister; Pavel Riha; Olga Neumüller; Oliver Danielewski; Jan Schultess
- Publisher
- BioMed Central
- Year
- 2007
- Tongue
- English
- Weight
- 181 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1471-2210
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Notch signaling is associated with prostate osteoblastic bone metastases and calcium/calmodulin‐dependent kinase II (CaMKII) is associated with osteoblastogenesis of human mesenchymal stem cells. Here we show that prostate cancer cell lines C4‐2B and PC3, both derived from bone metastas
## Abstract The biochemical differences among cGMP phosphodiesterases in platelets have not been thoroughly examined, primarily due to the lack of sufficient purified material. This report describes a simple method developed to isolate specific bovine platelet cGMP phosphodiesterase. This enzyme is
We studied the effects of endotoxin from Escherichiu coli (E. coli) on Ca2+ channel activity in PC12 cells using the cell-attached patch clamp technique. Endotoxin (1-100 nglml) decreased channel availability (n -Po) to about one third of control values, an effect that required 3.5 & 1 min (mean & S